DEC1:Deleted in esophageal cancer 1

Gene Name
Deleted in esophageal cancer 1
Protein ID
Chromosome ID
HPP Status
Protein Name
Deleted in esophageal cancer 1

candidate tumor suppressor CTS9


Candidate tumor suppressor CTS9

deleted in esophageal cancer 1

[Reference: ]
Chromosomal Position
9q33.1 | Start:115141818 End:115141818

Entrez Gene Summary for DEC1
The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. (provided by RefSeq, Jul 2008)

UniProtKB Summary for DEC1
Function: Candidate tumor suppressor

[Reference: ]
External IDs
Hgnc ID: 23658 EntrezGene ID: 50514 Ensembl ID: ENSG00000173077
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
15580306DEC1 is a candidate tumor suppressor gene that may be involved in esophageal squamous cell carcinoma development2010-01-21
17943723Decreased expression of candidate DEC1 is associated with esophageal carcinoma2010-01-21
19339270Observational study of gene-disease association. (HuGE Navigator)2009-04-22
19624270The hypoxia-regulated transcription factor DEC1 and its expression in gastric cancer are reported.2010-01-21
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
20935061DEC1 promoter -249 T>C (rs2012775) polymorphism is functional, modulating susceptibility to squamous cell carcinoma of the head and neck (SCCHN) among non-Hispanic Whites.2011-01-08
20935061Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-12-05
20975315DEC1 is down-regulated and tends to contribute to the migration ability of tumor cell lines; H3 K27 trimethylation potentially plays an important role in the regulation of DEC1 expression2011-05-07
21317427Study conclude that DeltaNp63 is a novel target of DEC1 and HDAC2 and modulates the efficacy of HDAC inhibitors in growth suppression and keratinocyte differentiation.2011-07-23
21779800DEC1 expression is correlated with HIF-1alpha protein in gastric cancer cell line.2012-06-30
21829689findings suggested that posttranslational modification of DEC1 in the form of SUMOylation may serve as a key factor that regulates the function of DEC1 in vivo2011-12-31
22644784IL-1beta can induce DEC1 and HIF-1alpha protein levels in gingival epithelial cells. We also demonstrate that the increase in DEC1 protein subsequently is followed by Akt phosphorylation.2013-01-12
22723347DEC1 controls the response of p53-dependent cell survival vs. cell death to a stress signal through MIC-12012-10-06
22728071findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex2012-10-20
22825629These findings suggest that DEC1 plays an important role in the regulation of these EMT-related factors in pancreatic cancer.2014-01-04
22844531DEC1 overexpression in precursor lesions of esophageal squamous cell carcinoma is a protective mechanism2012-12-08
23423709Loss of DEC1 may promote tumor progression in non-small-cell lung cancer through upregulation of cyclin D12013-07-20
23578198Sunitinib treatment performance could be attributable to TIS, depending on p53/Dec1 activation.2014-02-15
24100543The efficacy of inhibiting HIF-1alpha and DEC1 expression as a possible treatment for HCC should be assessed in clinical trials.2014-05-17
24404147DEC1 coordinates with HDAC8 to differentially regulate TAp73 and DeltaNp73 expression.2014-09-20
24758579The expression of DEC1 was associated with the incidence of oral squamous cell carcinoma (OSCC) and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC.2014-10-18
25202122USP17 binds and deubiquitylates DEC1, markedly extending its half-life. Subsequently, during checkpoint recovery, DEC1 proteolysis is reestablished through betaTrCP-dependent ubiquitylation.2015-02-14
25876658DEC1 has a pro-apoptotic effect on human esophageal cancer TE 10 cells of well-differentiated type.2016-01-16


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
All Reviewed HumanDEC1_HUMANDEC1_HUMAN7070100100001701703.00E-36146
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB